【小夏的论文笔记】母体叶酸补充可抵消发育期双酚A暴露引起的胰腺损伤和Igf2超甲基化

Pancreatic impairment and Igf2 hypermethylation induced by developmental exposure to bisphenol A can be counteracted by maternal folate supplementation
母体叶酸补充可以抵消发育期双酚A暴露引起的胰腺损伤和Igf2超甲基化

原文链接：http://onlinelibrary.wiley.com/doi/10.1002/jat.3430/full

这是一项动物实验研究。
双酚A（BPA）是一种被广泛生产的环境污染物，可以诱导DNA甲基化。并引发一些相关的疾病。
研究发现，暴露于BPA的大鼠中，母体通过膳食叶酸补充抵消了观察到的BPA诱导的后代胰腺损伤，包括胰岛素分泌障碍、葡萄糖不耐受和β细胞的形态和超微结构受损。这些胰腺功能障碍显示与发育期暴露于BPA诱导的胰岛中胰岛素样生长因子-2（Igf2）的低表达和DNA超甲基化有关。
研究证明了母体膳食叶酸补充被证明可以抵消后代中的这种Igf2 DNA超甲基化。

Abstract

Increasing evidence indicates that bisphenol A (BPA), a widely manufactured environmental pollutant, can induce changes in DNA methylation paatterns, which is a potential mechanism linking this environmental exposure to disease development. We investigated the influence of developmental exposure to BPA on pancreatic DNA methylation patterns and whether maternal folate supplementation can modify the epigenetic status and pancreatic impairment induced by BPA. Our results showed that maternal dietary folate supplementation in rats exposed to BPA counteracted the observed BPA-induced pancreatic impairments in the offspring, which included disrupted insulin secretion and glucose intolerance, and impaired morphology and ultrastructure of β cells. Moreover, these pancreatic dysfunctions were shown to be associated with low expression and DNA hypermethylation of insulin-like growth factor-2 (Igf2) in islets induced by exposure to BPA during the developmental period. Importantly, maternal dietary folate supplementation was demonstrated to negate this Igf2 DNA hypermethylation in the offspring, which was consistent with the upregulation of Igf2 expression. Overall, our results suggest that early developmental exposure to BPA alters the DNA methylation of Igf2, that these altered methylation patterns are associated with impaired β-cell function in the offspring and that these effects can be counteracted by maternal folate supplementation.


我们公卫有很多关于双酚A的毒理研究，还在华中科技大学主校区读书的时候，就听说之前洪山区喝东湖水，里面双酚A超标可能对孕妇有不良影响，后来武汉市政府觉得修建管道，改用长江水给洪山区供水。这项研究的重点是发现了一种可以抵消这种负面效应的方法，意义不言而喻。

读论文就发现自己掌握的知识还是太少了。现在只系统学习了卫统，最多也就看懂简单的流病调查，这种毒理的文章看起来还是有很多不懂的地方，还要继续努力学习啊。

冒冒知道吗

确实意义重大，说不定叶酸还有更多好处？楼主这么努力是打算做什么？

sativa 发表于 2017-6-15 16:56
确实意义重大，说不定叶酸还有更多好处？楼主这么努力是打算做什么？

准备一个去美国布朗大学的研习项目。