Fundamentals of Clinical Research (Statistics for Biology and Health)

By Antonella Bacchieri, Giovanni Della Cioppa,
# R2 x( \2 U. Y& b& C# @" A6 UPublisher:  Springer
9 B1 A/ e1 L/ `& U2 [8 jNumber Of Pages:  358
, T4 f6 |5 r' p1 _; ]Publication Date:  2007-02
* Z+ o. E  M0 p( S% Q9 ?+ MSales Rank:  862520
ISBN / ASIN:  8847004918
EAN:  9788847004917
Binding:  Hardcover
Manufacturer:  Springer
* M4 y9 l0 |7 M% R' KStudio:  Springer
5 @$ z! ^0 C8 t4 bAverage Rating:  
Total Reviews:
; P( w* P! b, d --------------------------------------------------------------------------------
% |  Q) J1 C" O. L4 i' MBook Description:
In recent years many introductory textbooks on clinical trial methodology have been published, some of which are excellent, in addition to a very extensive specialist literature. Nevertheless, here is a new book on methods and issues in clinical research. The objectives can be summarized in three points. 1. Integrate medical and statistical components of clinical research. 2. Do justice to the operational and practical requirements of clinical research. 3. Give space to the ethical implications of methodological issues in clinical research.
8 _5 [( q4 R  P6 A
1 f7 u. ]+ A: ?  l) aThe scope of clinical research is to evaluate the effect of a treatment on the evolution of a disease in the human species. The treatment can be pharmacological, surgical, psychological/behavioral or organizational/logistic. The disease, intended as an impairment of a state of well-being or a condition capable of provoking such impairment over time, can be universally accepted as such (e.g. a cancer or a bone fracture) or perceived as such only by limited groups of individuals in a given cultural context (e.g. hair loss or weight gain). The course of the disease that ones wishes to change can be the one with no intervention or, more frequently, the one observed with the available treatment. The evaluation of the effect of a treatment on the course of a disease is a lengthy process, which progresses in increasingly complex stages.

, Q# ^# c7 [. ~" X* ?6 rA detailed coverage of the logistic, administrative and legal aspects of clinical research is outside the scope of this book. However, throughout the book we keep reminding the reader of these aspects because, as already mentioned, we firmly believe they have a crucial role in determining the success of a study. The history of clinical research is paved with relics of studies started with great pomp, riding great ideas and great hopes, which drowned miserably because of inadequate logistical preparation. In our experience, the excessive complexity of a clinical trial is the single most frequent cause of failure: the study is perfect on paper, but impossible to implement by patients and staff alike. The distance between the principal investigators and the reality of clinical research in its day-to-day practice is often the main cause of such disasters. We warmly encourage everyone involved in clinical research to get involved in the logistics of a study, learning from colleagues responsible for its practical conduct (clinical research associates, data managers, etc.) and to take part, in person, in the practical implementation of a trial before attempting to design a study protocol.
2 Q! s1 o( w' m! w/ G' r
The book ends with a brief description of the drug development process and to the phases of clinical development.

游客，本帖隐藏的内容需要积分高于 10 才可浏览，您当前积分为 0

                               
登录/注册后可看大图

斑竹：不能下载呀！你还是共享吧！谢谢 ！

: V' w3 \! O3 ?) @) H3 J' V
可以下载的啊，那上面是可以免费下载的

  ?0 N; Q4 }' E2 Y8 P: [& \( H我给你传上来，要钢蹦：）