肿瘤临床试验中的非劣效性试验（十一）

 

上几篇博文，小胖简单介绍了Rothmann’s method，而基于fraction retention非劣效假设的常见方法还有：

 

（1）Hasselblad &Kong: CI for the ratio

 

Hasselblad V, Kong DF. Statistical methods for comparison to placebo in active-control trials. Drug Information Journal 2001; 35:435–449.

 

（2）Yong-Cheng Wang: Ratio test

 

Wang YC, Chen G, Chi GY.A ratio test in active control non-inferiority trials with a time-to-event endpoint.J Biopharm Stat. 2006;16(2):151-64.

 

（3）Richard Simon: Bayesian

 

Simon R. Bayesian design and analysis of active control clinical trials. Biometrics 1999; 55:484–487.

 

在这里小胖列出了主要方法的参考文献，有兴趣的同学可向小胖索取相关文献。