hoe to write a cover letter

看来论文写作板块还不热闹，我来抛点砖
cover letter的写法
不同杂志要求有所不同
主要这几个方面
1. main findings
2. significance
3. suggested reviewers
4. “not to review” list
5. who have read
以下有3个examples
声明：example1和example2来自丁香园，example3是复旦大学马兰教授的讲稿
Example1:
Dear Editor,
We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.
GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.
Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am
Sincerely yours,
NAME,ADRESS,EMAIL,FAX

Example2
Dear Editors:
On behalf of my co-authors, I am submitting the enclosed material “ TITLE ” for possible publication in JOURNAL.
We certify that we have participated sufficiently in the work to take public responsibility for the appropriateness of the experimental design and method, and the collection, analysis, and interpretation of the data.
We have reviewed the final version of the manuscript and approve it for publication. To the best of our knowledge and belief, this manuscript has not been published in whole or in part nor is it being considered for publication elsewhere.
Best Regards.
Yours Sincerely,
NAME,ADRESS,EMAIL,FAX

Example3
Dear Dr. Wieland:
We have enclosed the manuscript “Activation of tyrosine kinase of EGFR induces GRK-EGFR binding and this requires Gβγ subunits” by Gao et al for consideration as an article in FEBS Letters.
GRKs mediate agonist-induced phosphorylation and desensitization of numerous GPCRs. Our previous studies demonstrated that GRKs play critical roles in regulation of phosphorylation and desensitization of GPCR signal transduction (Li J et al, 2003 J Biol Chem. 278:30219-30226; Xiang B et al 2001 J Biol Chem 276: 4709-4716; Guo J et al 2000 Mol Pharmacol 58:1050-1056). Recent studies showed that GRKs also play an important role in receptor tyrosine kinase signaling, but the underlying mechanisms are not well understood. Here we demonstrate in this report that activation of EGFR tyrosine kinase induces GRK-EGFR binding and this involves a Gβγ-mediated mechanism. We feel that the potential significance of our findings related to receptor tyrosine kinase and GRKs should be of general and immediate interest to the broad scientific community and the readership of FEBS Letters. We hope you will concur with our assessment.
We would like to suggest Dr. xxx as the editor of this manuscript, and Drs. xxx (xxx@strath.ac.uk), xxx (xxx@uchsc.edu) and xxx (xxx@cbm.uam.es) as reviewers of manuscript.
Thank you for your consideration.
Sincerely,
（signature）
xxx, Ph. D.
Professor of Pharmacology
Shanghai Medical College
Fudan University

"hoe to write a cover letter" should be “how to write a cover letter ”