Pandemic Flu | Seasonal Flu |
| Rarely happens (three times in 20th century) | Happens annually and usually peaks in January or February |
| People have little or no immunity because they have no previous exposure to the virus | Usually some immunity built up from previous exposure |
| Healthy people may be at increased risk for serious complications | Usually only people at high risk, not healthy adults, are at risk of serious complications |
| Health care providers and hospitals may be overwhelmed | Health care providers and hospitals can usually meet public and patient needs |
| Vaccine probably would not be available in the early stages of a pandemic | Vaccine available for annual flu season |
| Effective antivirals may be in limited supply | Adequate supplies of antivirals are usually available |
| Number of deaths could be high (The U.S. death toll during the 1918 pandemic was approximately 675,000) | Seasonal flu-associated deaths in the United States over 30 years ending in 2007 have ranged from about 3,000 per season to about 49,000 per season. |
| Symptoms may be more severe | Symptoms include fever, cough, runny nose, and muscle pain |
| May cause major impact on the general public, such as widespread travel restrictions and school or business closings | Usually causes minor impact on the general public, some schools may close and sick people are encouraged to stay home |
| Potential for severe impact on domestic and world economy | Manageable impact on domestic and world economy |
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