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本帖最后由 sampson2010 于 2014-12-26 11:07 编辑
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Title: Modern Clinical Trial Analysis
9 `5 {1 S4 [ y6 [4 B cAuthor(s): Changyong Feng, Yu Han, Pan Wu, Xin Tu (auth.), Wan Tang, Xin Tu (eds.)
f2 B3 u0 Q) s$ }/ l2 sSeries: Applied Bioinformatics and Biostatistics in Cancer Research
- s* y. a7 }# T3 `8 fPublisher: Springer New York
3 F& i7 M, L# J% j+ iYear: 2013
( @4 w `4 A' z: |, ^4 V7 u; C4 VLanguage: English
7 U# u2 ^$ _' b2 t0 Q, zPages: IX, 253 p. 15 illus., 1 illus. in color.
. @# Y5 ^, C) A) i2 V& ~0 iISBN: 978-1-4614-4321-6, 978-1-4614-4322-3
% W" y+ i6 f: O; ?9 i" \4 lSize: 3 MB (2645092 bytes)
- g, c1 {4 [. Z+ w# P( ?$ TExtension: pdf. M3 C. O' T7 N) j
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This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. Starting with survival data analysis, this book transitions from such a classic topic to modern issues by stepping through diagnostic test and instrument assessment, sequential and dynamic treatment regimen, cost-effectiveness evaluation, equivalence testing. As some type of cancer such as the effect of smoking on lung cancer cannot be studied using randomized trials, a chapter on analysis of non-randomized studies is also included. The book concludes with a chapter discussing the opportunities and challenges that lie ahead in developing on person-centered treatment regimens.
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The book provides an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out the analyses. Medical researchers with some background in clinical trial design and regression analysis as well as biostatisticians will find this book informative and helpful. 5 }! [" }2 m2 ~; N# `+ x
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Table of contents :
) O N m* U1 \* zContent: 8 f a) o7 w: C" P# [
Front Matter....Pages i-ix
) l c# {+ k- f f' WSurvival Analysis....Pages 1-23: I6 Z+ M7 ]) c9 D4 a$ d3 u
Longitudinal Data Analysis....Pages 25-53
7 g7 N& _ P) h. J% _. O8 q8 p1 JAssessment of Diagnostic Tests and Instruments....Pages 55-79
* l! }) e* c* ]2 E4 @Analysis of Sequential Clinical Trials....Pages 81-125) ~4 G3 h6 ^: b3 H
Dynamic Treatment Regimes....Pages 127-148
; F5 l# @: U4 B! O3 g+ bStatistical Issues with Trial Data and Economic Modeling for Cost-Effectiveness Evaluation....Pages 149-166( F, ^% W/ A. V3 e8 Z4 H, s; u [2 E2 O h8 B
Active-Controlled Clinical Trials....Pages 167-182
6 P/ Q/ }- Y3 }$ a! T! jThorough QT/QTc Clinical Trials....Pages 183-201 |/ ^. }0 V5 ^; R( M+ q9 {' l" c7 Y
Causal Inference in Cancer Clinical Trials....Pages 203-225) h# }& J9 c2 z5 k, N
Changing Paradigms in Cancer Clinical Trials....Pages 227-246 L! s% k6 h {1 S! Z+ f4 j$ p
Back Matter....Pages 247-253/ l/ T2 X) R! d) q
Modern Clinical Trial Analysis.pdf
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