NIH专家委员会：预防Alzheimer病，目前尚无良方

iavjssssmqee · 发表于 2010-5-5 16:59:58

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Prevent Alzheimer's? No evidence you can: panel

(Reuters) - Fish oil, exercise and doing puzzles may all be good for the brain but there is no strong evidence that any of these can prevent Alzheimer's disease, an expert panel concluded on Wednesday.

Nor can any other supplements, drugs or social interaction, the independent panel meeting at the National Institutes of Health outside Washington concluded.

The group of experts looked at the dozens of studies that have suggested ways to prevent Alzheimer's -- a devastating and incurable breakdown of the brain -- and found none were strong enough to constitute proof.

"We wish we could tell people that taking a pill or doing a puzzle every day would prevent this terrible disease, but current evidence doesn't support this," said Dr. Martha Daviglus of Northwestern University in Chicago, who chaired the panel.

Most of the studies that have been done show associations, but not cause and effect, Daviglus said.

"These associations are examples of the classic chicken or the egg quandary. Are people able to stay mentally sharp over time because they are physically active and socially engaged or are they simply more likely to stay physically active and socially engaged because they are mentally sharp?" she asked.

The 15 experts met under the NIH's state-of-the-science conference program, which aims to direct future research in an important study area.

They included specialists in geriatrics, long-term care, nursing, psychiatry and other fields. Panelists may not be federal government employees, nor may they have financial stakes in any treatments considered.

DISEASE NOT FULLY UNDERSTOOD

The Alzheimer's Association says as many as 5.3 million Americans have Alzheimer's and projects that 16 million may have it by 2050.

"It is critical that we, as a nation, significantly increase investments in Alzheimer research," the group said in a statement.

"The total payments for health and long-term care services for people with Alzheimer's and other dementias will amount to $172 billion from all sources in 2010."

The panel found there were inconsistent definitions of what constitutes Alzheimer's disease and the cognitive decline that leads up to it.

Doctors also do not fully understand how the disease develops -- for instance, there is disagreement on whether the amyloid plaques found in the brains of victims cause the disease or are merely a symptom.

There are a few drugs to treat Alzheimer's but their effects are temporary. Genetics are strongly involved, and blacks and other minorities have a higher risk than whites.

http://www.reuters.com/article/idUSTRE63R5TI20100428

iavjssssmqee · 发表于 2010-5-5 17:02:50

NIH专家委员会：预防Alzheimer病，目前尚无良方

路透社—国立卫生研究院在华盛顿郊外举行的一个专家委员会星期三得出总结意见：尽管鱼油、锻炼和做拼图有益于大脑，但缺乏有力证据支持这些措施能够预防阿尔茨海默病。任何补充剂、药物或社会干预措施都不能预防阿尔茨海默病。
专家小组回顾了数十个关于预防阿尔茨海默病方法的研究，却未发现任何强有力证据支持的方法能够预防这种大脑进行性不可逆衰退的疾病。

专家委员会主席芝加哥西北大学Martha Daviglus博士表示，我们也希望通过每天口服药物或做拼图就可以预防这种可怕的疾病，但目前尚无证据证明这种方法有效。以往的许多研究显示了两者之间具有某种相关性，但并非因果关系。这种关系就如同经典的“先有鸡后有蛋”还是“先有蛋后有鸡”的争论一样：人们因为活动锻炼和社会实践才能够保持精神敏锐，还是因为精神敏锐才能够进行活动锻炼和社会实践？

这由老年病学、康复科学、护理学、儿科学及其他学科组成的15名专家是因国立卫生研究院前沿科学会议方案相聚一堂，目的是为了指出某一重要领域的研究动向。他们既非联邦政府雇员，也不与讨论的治疗措施之间存在任何经济利益。

未完全了解的疾病.

阿尔茨海默病协会工作人员称目前大约有五百三十五万美国人患有此病，预计到2050年患病人数将达到一千六百万。预计2010年阿尔茨海默病及其他痴呆患者进行治疗和长期护理所需费用将高达一千七百二十亿美元。故委员会小组在声明中呼吁，在全国范围内进行阿尔茨海默病研究的投资刻不容缓。

同时专家组发现，关于阿尔茨海默病的病因和认知功能减退导致的阿尔茨海默病的定义，目前缺乏统一认识。临床医生同样还没有完全了解阿尔茨海默病的发病机理，比如在患者脑组织中发现的淀粉样斑块究竟是致病因素或仅仅是一种现象尚存在分歧。

目前有少数药物临床上用于治疗阿尔茨海默病，但疗效短暂。此病有较强的遗传倾向，黑种人及其他少数族裔较白种人有更高的发病风险。

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[分享] NIH专家委员会：预防Alzheimer病，目前尚无良方

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