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Multiple metals exposure, elevated blood glucose and dysglycemia among Chinese occupational workers
多种金属暴露与中国职工的高血糖和血糖代谢障碍
原文链接:http://www.sciencedirect.com/sci ... i/S1056872716303014
这是一项基于金昌队列基线数据的横断面分析。
通过Logistic回归模型分析了尿中各元素水平和空腹血糖水平、血糖代谢障碍之间的关系。发现尿镍水平的增高与高空腹血糖水平相关,尿锌也与高空腹血糖水平正相关,但尿钴呈负相关。尿镍和尿锌与血糖代谢障碍正相关,但尿镍的关系无统计学意义,尿砷和血糖异常之间有关联。没有发现尿铜、镉和高血糖、血糖代谢障碍之间的关联。
【Abstract】
Aims
Exposure to metals may adversely affect cardiometabolic health. The aim of this study is to directly evaluate the roles of multiple metals exposure in glucose homeostasis, the dysfunction of which has been linked to diabetes and cardiovascular diseases (CVDs).
Methods
We performed a cross-sectional analysis of baseline data from 464 metal-exposed workers who participated in a large prospective occupational study in China (Jinchang Cohort). The logistic regression model was used to evaluate the association between urinary metal levels and high fasting plasma glucose (high-FPG) (≥ 75th percentile) and dysglycemia.
Results
Increasing levels of urinary nickel were prospectively associated with high-FPG: multivariable odds ratios (ORs) were 1.00 for the 1st quartile (lowest), 1.20 (95% confidence interval [CI]: 0.60–2.43) for the 2nd quartile, 1.64 (0.78–3.49) for the 3rd quartile and 3.17 (1.38–7.30) for the 4th quartile (highest) (P-trend = 0.004). The positive associations were also observed between urinary zinc and high-FPG (4th vs. 1st quartile = 2.71, 95%CI: 1.26–5.84, P-trend = 0.01). Inverse associations between urinary cobalt and risk of high-FPG and dysglycemia were observed (P-trend < 0.05). For dysglycemia, the positive trends of increasing levels of urinary nickel and zinc still remained, although urinary nickel was no longer statistically significant. A significant association between urinary arsenic and dysglycemia was also found. However, no associations were observed between urinary copper, cadmium, and risk of high-FPG or dysglycemia.
Conclusion
Multiple urinary metals, particularly arsenic, nickel, zinc, and cobalt, were associated with elevated blood glucose among Chinese occupational workers, supporting the notion that metal exposure plays a critical role in the development of diabetes.
Keywords
Metal; Glucose; Dysglycemia; Diabetes; Occupation
顺便搜了一篇金昌队列的介绍,是“全球唯一的大样本金属暴露队列研究平台”:
http://d.wanfangdata.com.cn/Periodical/lanzyxyxb201506005 |
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