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[其他话题] 【小夏的论文笔记】产前镉暴露危险窗口和出生体格

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夏鹏飞 发表于 2017-5-2 23:25:12 | 显示全部楼层 |阅读模式

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本帖最后由 夏鹏飞 于 2017-5-3 09:01 编辑

Critical Windows of Prenatal Exposure to Cadmium and Size at Birth
产前镉暴露危险窗口和出生体格

原文地址:http://www.mdpi.com/1660-4601/14/1/58/htm


这个研究的样本没有此前几篇这么多,只有282对母婴纳入研究。
该研究通过广义估计方程模型评估各孕期孕妇肌酐调整的尿镉浓度与出生体格之间的关系。
发现早孕期中母体尿镉浓度与女婴体重呈负对数相关,尿镉浓度每增加一个对数单位(μg/g肌酐) ,出生体重减少116.99 g(95%置信区间(CI):-208.87,-25.11g),并且各孕期组间尿镉浓度与出生体重关联程度不同,女婴结果也不同,但P=0.08,统计学意义并不强。男婴出生体重与孕期镉暴露无关。

Abstract: Prenatal cadmium (Cd) exposure has been associated with adverse birth outcomes, but the findings of previous studies are inconsistent. We measured Cd concentrations in urine samples at or near 13, 24, and 35 gestational weeks from 282 women in Wuhan, China. We used generalized estimating equation models to assess the associations between maternal creatinine adjusted urinary Cd concentrations at each trimester and birth size. A significant inverse association was observed between higher maternal Cd levels measured during the 1st trimester and birth size in girls. For each log unit increase in Cd (μg/g creatinine) levels from the 1st trimester, there was a decrease in birth weight by 116.99 g (95% confidence interval (CI): −208.87, −25.11 g). The Cd levels from the 1st and 2nd trimesters were also borderline significantly associated with ponderal index in girls. Joint estimation of trimester-specific effects suggested that associations with Cd levels for ponderal index (pint = 0.02) were significantly different across trimesters, and differences for effects across trimesters for birth weight were marginally significant (pint = 0.08) in girls. No significant associations were observed between Cd levels from any trimester and birth size in boys. Maternal Cd exposure during earlier periods of pregnancy may have a larger impact on delayed fetal growth.

Keywords: cadmium; birth weight; fetal exposure; critical window; epidemiology


学到了borderline significant和marginally significant这两个表达,正好我的文章里面有一个P=0.0507,可以用一下这个表达。

广义估计方程模型是一个新概念,网上找到一个PPT简单了解一下:
https://wenku.baidu.com/view/8e6b656327d3240c8447ef20.html

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epiman 发表于 2017-5-2 23:45:00 | 显示全部楼层
trimester 产科词汇,指的是孕早期、孕中期和孕晚期的一期

有道字典上就有啊
one of the three-month periods of pregnancy 〔妊娠三期中的〕一期
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 楼主| 夏鹏飞 发表于 2017-5-3 07:56:00 | 显示全部楼层
epiman 发表于 2017-5-2 23:45
trimester 产科词汇,指的是孕早期、孕中期和孕晚期的一期

有道字典上就有啊

学习了,多谢老大,平时电脑用的是海词,看来还是要多查一查才是。
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