公卫人

 找回密码
 立即注册

QQ登录

只需一步,快速开始

不劳无获:如何获取钢镚? 因为论坛,所以相逢。 捐赠百科答题至尊

公卫考研:一起风雨兼程 因为梦想,所以努力。 真题答案政治英语

职称考试:诸君逢考必过 因为热爱,所以执着。 模拟考场技能执医中级

查看: 1430|回复: 3

[分享] Sample Size Calculations in Clinical Research

[复制链接]
epiman 发表于 2015-10-12 15:31:42 | 显示全部楼层 |阅读模式

注册后推荐绑定QQ,之后方才可以使用下方的“用QQ帐号登录”。

您需要 登录 才可以下载或查看,没有帐号?立即注册

x
Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research& m  Q( m% D2 b! H7 F" b( l; X

) M1 O" d$ _1 A) [+ @4 _3 t                               
登录/注册后可看大图
( b1 L7 m& @3 s/ R9 r9 H

; e, N, j( k! l& K0 o) S7 M7 X& cFeatures
  • Discusses sample size determination for independent outcomes as well as variants of clustered trials, including one- and two-sample trials for continuous and binary outcomes, stratified cluster design, and nonparametric approaches
  • Presents sample size methods based on summary statistics of longitudinal outcomes
  • Explains how to determine sample size using GEE approaches for various types of correlated outcomes, including continuous, binary, and count
  • Describes mixed-effects model approaches for randomized clinical trials with two level data structures
  • Extends the mixed-effects model sample size approaches to scenarios where three level data structures are involved in randomized trials
    5 C8 x7 [: @. x9 _
SummaryAccurate sample size calculation ensures that clinical studies have adequate power to detect clinically meaningful effects. This results in the efficient use of resources and avoids exposing a disproportionate number of patients to experimental treatments caused by an overpowered study.
) b% I+ [- B8 \3 }2 d$ v4 oSample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies.- }9 J" u: o! ]+ q$ I

8 ~; O) ?' d5 _2 xThe book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement.
& |/ y$ `- q" C# R% W/ V4 S* Q$ B  G8 B
; ~& v3 ]' b3 j4 |( }' ~Addressing the overarching theme of sample size determination for correlated outcomes, this book provides a useful resource for biostatisticians, clinical investigators, epidemiologists, and social scientists whose research involves trials with correlated outcomes. Each chapter is self-contained so readers can explore topics relevant to their research projects without having to refer to other chapters.
. P! R" h6 b1 N' J
& |; Y% i- T! `+ q
1 n- z. \% z' Z) [' i' j2 X/ d  U

Sample Size Calculations in Clinical Research.pdf

2.07 MB, 下载次数: 19, 下载积分: 金钱 -1 钢镚

售价: 1 钢镚金钱  [记录]

本帖被以下淘专辑推荐:

 楼主| epiman 发表于 2015-10-12 15:33:23 | 显示全部楼层
Table of Contents9 n; W+ o/ C+ ^( [% E, `8 H
0 E- S* Z  c. H( O! w+ _) F$ Y
Sample Size Determination for Independent Outcomes   D6 o7 J8 P% P
Introduction   |3 d+ J$ S0 J- t
Precision Analysis
( Z3 h. o7 ^5 L7 U- yPower Analysis - {- }2 _- z, W1 g

# P5 U" a1 ]7 w0 E4 G1 r- ?, a; i' M8 c7 s0 E1 D: i' ?
Sample Size Determination for Clustered Outcomes ' \6 O" G. d2 p$ k' \/ V
Introduction
: M: U- y; W) m9 FOne-Sample Clustered Continuous Outcomes
: ~8 H6 F7 E5 N* d. HOne-Sample Clustered Binary Outcomes
1 i# W+ i6 Y; ~  F1 PTwo-Sample Clustered Continuous Outcomes
, O) s' ^; {& T+ e; D# x( LTwo-Sample Clustered Binary Outcomes + Q6 {3 {* A- c( `' {5 Q
Stratified Cluster Randomization for Binary Outcomes
5 h% C- _7 b& s. n8 UNonparametric Approach for One-Sample Clustered Binary Outcomes
2 s4 a7 s! ]( ~3 o
0 u8 ~  q3 V9 [# Q6 o! ]- E6 X; w5 _; F6 O" y( P
Sample Size Determination for Repeated Measurement Outcomes Using Summary Statistics
! p0 ~' u* k/ b. Z9 OIntroduction
5 |8 s0 e+ i$ {Information Needed for Sample Size Estimation
7 R' @! R9 w4 [Summary Statistics 3 H+ G* b3 G" E3 v) B
) F- h4 t1 ]$ L

4 c( w# l7 v. D' R) e( SSample Size Determination for Correlated Outcome Measurements Using GEE ! J+ G# `$ V. |- G
Motivation
: f9 D# c, j+ e& Z" |Review of GEE
5 K# r1 y; h/ _% {! _Compare the Slope for a Continuous Outcome $ u  L' E4 [2 T% t: `
Test the TAD for a Continuous Outcome - G& K! X; q% O& Z* y# ]5 I
Compare the Slope for a Binary Outcome
+ @1 p1 v3 c9 a5 r, T2 b/ }Test the TAD for a Binary Outcome
7 @# ]1 a% `; @8 m7 C& G" N% \Compare the Slope for a Count Outcome
  A( Y2 M' ^$ Q* W/ JTest the TAD for a Count Outcome
* `2 T3 v- Z/ y$ ]( k0 |5 W
: s$ t: x8 m+ R$ s3 s
0 A5 e$ J0 o" a/ o( NSample Size Determination for Correlated Outcomes from Two-Level Randomized Clinical Trials
% t# b0 p2 K+ E, r1 r. t4 {) VIntroduction % S) K9 p$ @. m7 U
Statistical Models for Continuous Outcomes
6 R. T; d% B- c# t3 ATesting Main Effects 9 h; K; e  C  J
Two Level Longitudinal Designs: Testing Slope Differences   }3 j) F3 K2 R* ?; E0 J
Cross-Sectional Factorial Designs: Interactions between Treatments
. U4 L5 }( B9 o4 yLongitudinal Factorial Designs: Treatment Effects on Slopes 7 D) z  t6 c+ Y9 s. h4 V
Sample Sizes for Binary Outcomes
, d; c7 W: v2 m& a
& ]( ]0 R( S, @; e9 Y( D' V5 G8 d  |# h' y: V
Sample Size Determination for Correlated Outcomes from Three Level Randomized Clinical Trials
( p% H: g: t4 G, A& nIntroduction % s* T' {# |; u7 y$ [
Statistical Model for Continuous Outcomes : C, V7 ^9 k6 G8 c/ B' @$ h
Testing Main Effects
* e8 ~6 _  N" C# F7 e" v/ @9 FTesting Slope Differences : \" l9 h4 k' k# M! A" D8 j" m
Cross-Sectional Factorial Designs: Interactions between Treatments 6 Q4 O; B% ]" c" U4 h- |" }
Longitudinal Factorial Designs: Treatment Effects on Slopes
" s: a/ ]4 E; d+ n: `0 |) \8 zSample Sizes for Binary Outcomes , P  L$ I1 _$ e4 B

  Q2 B3 h; z% |& x
9 }' X8 u9 u/ o' `: RFurther Readings appear at the end of each chapter.
9 j& I2 S0 x$ d5 Q5 q- ?
回复

使用道具 举报

 楼主| epiman 发表于 2015-10-12 15:34:00 | 显示全部楼层
Author(s) Bio
" R9 ]$ N$ W# T' n0 Q' b+ m8 ^0 k8 C' h5 }' a% a) {: t
Chul Ahn, PhD, is a professor in the Department of Clinical Sciences and the cancer center associate director for biostatistics and bioinformatics in the Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center. He is also director of Biostatistics and Research Design for the NIH-sponsored Clinical and Translational Science Award (CTSA). He has published more than 370 peer-reviewed papers addressing the design and analysis of clinical trials and epidemiological studies as well as the evaluation of repeated measurements and correlated data.
/ }- U' Y0 N4 g
1 n! F3 T0 b  D" sMoonseong Heo, PhD, is a professor in the Department of Epidemiology & Population Health at the Albert Einstein College of Medicine. His research includes sample size determinations for clinical trials, meta-analysis, longitudinal data analysis applying mixed-effects models, handling attrition problems in clinical trials data, and epidemiology in the fields of obesity and psychiatry. $ i4 s5 _! u2 B5 E: o4 |

" _9 s: G: A" o6 bSong Zhang, PhD, is an associate professor in the Department of Clinical Sciences at the University of Texas Southwestern Medical Center. He has extensive experience in the design of clinical trials with correlated outcomes, addressing challenges that involve different correlation structures, missing data patterns, financial constraints, and historical controls. He is also interested in Bayesian statistical methods and their application in longitudinal and survival data analysis, high-throughput data analysis, disease mapping, adaptive design for clinical trials, and missing data imputation.4 Y& q7 f# X) X& c2 D
回复

使用道具 举报

jiran666 发表于 2018-1-19 10:04:22 | 显示全部楼层
请问有中文版吗
回复

使用道具 举报

您需要登录后才可以回帖 登录 | 立即注册

本版积分规则

手机触屏版|捐赠|关于|接种|公卫人 ( 沪ICP备06060850号-3 )

GMT+8, 2018-2-25 02:01 , Processed in 0.108601 second(s), 39 queries , Gzip On, MemCache On.

Powered by Discuz! X3.4

© 2001-2017 Comsenz Inc.

快速回复 返回顶部 返回列表